Development of Novel Image Analysis and Modeling Tools to Examine Mechanisms of Muscle Damage in Duchenne Muscular Dystrophy

Emily Miller
DMD is a devastating X-linked recessive musculoskeletal disorder that effects 1 in 3500 boys. DMD is caused by the lack of a functional dystrophin protein, a structural protein that mechanically links muscle fibers to the extracellular material. Without dystrophin, muscle fibers are more susceptible to contraction induced damage.Therefore, everyday movements such as walking, talking, and breathing result in cycles of muscle degeneration and regeneration, ultimately leaving affected individuals wheelchair users by their early teens, and...
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