Mechanisms of IL-33-mediated protection during C. difficile colitis

Alyse Frisbee
Clostridium difficile (C. difficile) incidence has tripled over the past 15 years and is attributed to the emergence of hypervirulent strains. While it is clear that C. difficile toxins cause damaging colonic inflammation, the host immune mechanisms protecting from tissue damage require further investigation. Through a transcriptomics array, we identify IL-33 as an immune target upregulated in response to hypervirulent C. difficile infection. We demonstrate that IL-33 prevents C. difficile-associated mortality and epithelial disruption independently...
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