Novel Computational Tools for Linking Genotypes to Microbial Community Phenotypes

Matthew Biggs
The human microbiome is vital to human health as a metabolic “organ” with essential catabolic and anabolic functions. Development of microbiome-targeted therapies requires mechanistic understanding of how microbes interact with each other and with the host. Mechanistic computational approaches can increase knowledge gains from experiments, infer system properties that are difficult to measure, and accelerate the design of novel therapies. Constraint-based reconstruction and analysis (COBRA) of genome-scale metabolic networks is a powerful mechanistic approach that...
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