Structural and functional studies of the Hfq family of ancient bacterial RNA-binding proteins

Kimberly Stanek
The bacterial host factor Hfq is an RNA-binding protein that facilitates the interaction of mRNAs with small regulatory RNAs (sRNAs) Hfq self-assembles as hexameric toroid and functions by simultaneously binding U-rich regions of sRNA on one face and A-rich regions of mRNA on the other face. More recently a third site on the lateral rim of Hfq has been implicated in binding RNA, though little is known about the molecular details of RNA-binding at this...
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