Prefrontal Cortical Deletion of DNA Methyltransferases Dnmt1 and Dnmt3a Reduces Palatable Food Intake

Jonathan Joy-Gaba
DNA methylation is an epigenetic mechanism most often associated with the repression of gene expression; mediated by the DNA methyltransferases (DNMT). Expression of both DNMT1 and DNMT3a isoforms within post-mitotic neurons of the central nervous system (CNS) has been shown to be important in modulating the response to drugs of abuse and other stimuli that produce changes in neuronal plasticity. Interestingly, DNMT1 and DNMT3a expression has been shown to be dynamically regulated in the medial...
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