Systems Biology Approaches for Studying Phosphatase Activity in Coxsackieviral Heart Disease

Millie Shah
Viruses are ancient pathogens that infect host cells and hijack their intracellular machinery. Most viruses, like the cardiotropic picornavirus coxsackievirus B3 (CVB3), engage several intracellular signaling pathways during infection through the expression of viral nucleic acid and proteins. During acute infection, these perturbations serve to condition the cell for optimal viral replication and release, while also avoiding immune surveillance. In chronic infections, where virion release is rare, these same perturbations cause long-term cellular dysfunction. For...
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