Agent-based modeling of the glioblastoma tumor microenvironment

Lynette Sequeira
Effects of the tumor microenvironment on cancer progression and malignancy has recently become a common theme when determining therapeutic efficacy and strategies. In fact, in glioblastoma (GBM), the most malignant brain cancer in adults, tumor microenvironmental components have previously been implicated in tumor progression and malignancy. Thus, in this study, we set out to experimentally and computationally recapitulate the effects of the two most abundant stromal GBM cells, astrocytes and microglia, on tumor cell survival...
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