Interleukin 33 Initiates CNS Inflammation Following Traumatic Injury

Sachin Gadani
Inflammation is a prominent feature of CNS injury that heavily influences neuronal survival, yet the signals that initiate and control it remain poorly understood. In this thesis I describe two linked projects that attempt to address this question. In the first, we identified the nuclear alarmin, interleukin (IL)-33, as an important regulator of the innate immune response after CNS injury. IL-33 is expressed widely throughout the healthy brain and is concentrated in white mater due...
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