Diacylglycerol Kinase α is a Pharmacologically Targetable Immune Regulator with a Newly Identified Role in Macrophage Activation

Laryssa Manigat
The diacylglycerol kinases (DGKs) are a family of lipid kinases whose primary function is the conversion of diacylglycerol (DAG) to phosphatidic acid (PA). There has been mounting evidence indicating that DGK enzymes are implicated in other physiologic processes, ranging from immune cell regulation to cancer progression. DGKα in particular is a known promoter of T-cell anergy, and has been demonstrated as a promising therapeutic target in multiple cancers including glioblastoma (GBM) and melanoma. Prior to...
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