Strategies for rational protein engineering of cytochrome P450 monooxygenase systems

Lukasz Gricman
Cytochrome P450 monooxygenases (CYPs) constitute a large and diverse protein family. Because of their ability to introduce molecular oxygen into non-activated C-H bonds, CYPs are interesting enzymes for synthetic applications. However, stability, selectivity and activity are often obstacles prohibiting those enzymes from being used in industrial processes. Thus, novel protein engineering strategies for overcoming all those bottlenecks are required. In this work, a comprehensive guide to protein engineering of CYPs covering those three aspects was...
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