Histopathology of shock wave treated tumor cell suspensions and multicell tumor spheroids

Thomas Bräuner, Franz Brümmer & Dieter F. Hülser
L1210 mouse leukemia cell suspensions exposed to 500 shock waves (SW) in an experimental lithotripter (XLI, Dornier) revealed severe cellular damage. Apart from cell fragments and cellular debris, cells exhibited alterations of shape, vacuolisation of the cytoplasm, perinuclear cisternae, swelling of mitochondria or rupture of the mitochondrial fine structure, and permeabilization of the cell membrane. Treatment of multicell tumor spheroids of both HeLa and EMT6/Ro cells in suspension with 500 SW resulted either in loss...
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