Analysis of receptor-receptor interactions and their implications on the formation of signaling competent TRAIL receptor clusters

Simon Paul Neumann
The cytokine tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and its associated receptors constitute an elaborate signaling system fulfilling important functions in regulation of the immune system and in tumor surveillance. Two TRAIL membrane receptors, receptor 1 (TRAILR1) and receptor 2 (TRAILR2), possess an intracellular death domain. Activation of these receptors can lead to apoptosis in TRAIL susceptible cells, but also non-apoptotic signals can be induced. Two additional TRAIL receptors, TRAILR3 and TRAILR4, are generally referred...
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