Combinations of costimulatory antibody-ligand fusion proteins for targeted cancer immunotherapy

Nora Hornig
Combinatorial strategies are of emerging interest in cancer immunotherapy. Costimulation by individual members of the Ig- or TNF-superfamily have already revealed promising antitumor potential, thus prompting the exploration of their synergistic abilities in combinatorial approaches. Here, in order to avoid systemic side effects, costimulation was restricted to the tumor site by pursuing a targeted strategy with antibody-ligand fusion proteins composed of tumor antigen-directed antibodies and the extracellular domain of the costimulatory ligands B7 or 4-1BBL,...
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