Mathematical modeling of signal transduction pathways in mammalian cells at the example of the EGF induced MAP kinase cascade and TNF receptor crosstalk

Birgit Schoeberl
In this work we apply mathematical modeling to signal transduction networks in mammalian cells. In particular, we have developed models for a survival pathway, the EGF induced MAP kinase cascade and an apoptotic signal trans-duction network the TNF receptor crosstalk. The models presented here are based on and were validated with own experimental data. In the field of signal transduction the major proteins involved and their interactions are fairly well known and biochemically characterized ....
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