Assemblage of ortho cleavage route for simultaneous degradation of chloro- and methylaromatics

Fernando Rojo, Dietmar H. Pieper, Karl-Heinrich Engesser, Hans-Joachim Knackmuss & Kenneth N. Timmis
Genetic engineering is a powerful means of accelerating the evolution of new biological activities and has considerable potential for constructing microorganisms that can degrade environmental pollutants. Critical enzymes from five different catabolic pathways of three distinct soil bacteria have been combined in patchwork fashion into a functional ortho cleavage route for the degradation of methylphenols and methylbenzoates. The new bacterium thereby evolved was able to degrade and grow on mixtures of chloro- and methylaromatics that...
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