RAG1/2 induces genomic insertions by mobilizing DNA into RAG1/2-independent breaks

Philipp Christian Rommel
The RAG recombinase (RAG1/2) plays an essential role in adaptive immunity by mediating V(D)J recombination in developing lymphocytes. In contrast, aberrant RAG1/2 activity promotes lymphocyte malignancies by causing chromosomal translocations and DNA deletions at cancer genes. In addition, RAG1/2 can induce aberrant DNA insertions by transposition and trans-V(D)J recombination, but only few putative such events have been documented in vivo. Moreover, those observed in cancer display characteristics that are not compatible with either DNA transposition...
This data repository is not currently reporting usage information. For information on how your repository can submit usage information, please see our documentation.