Evolution of the antagonistic tumor necrosis factor receptor one-specific antibody ATROSAB

Fabian Richter
The pleiotropic cytokine tumor necrosis factor (TNF) is involved in numerous processes of human physiology and its dysregulated expression affects multiple, mainly inflammatory or autoimmune diseases. Thus, TNF-neutralizing therapeutics are highly successful in the treatment of e.g. rheumatoid arthritis or Crohn's disease. However, the resulting blockade of both TNF receptors (TNFR1 and TNFR2) led to diverse, sometimes serious side effects. Recently, the detrimental effects of chronic TNF activity were attributed to TNFR1 and hence, its...
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