Pancreatic cancer biomarkers discovery by surface-enhanced laser desorption and ionization time-of-flight mass spectrometry

Filippo Navaglia, Paola Fogar, Daniela Basso, Eliana Greco, Andrea Padoan, Loris Tonidandel, Elisa Fadi, Carlo-Federico Zambon, Dania Bozzato, Stefania Moz, Roberta Seraglia, Sergio Pedrazzoli & Mario Plebani
Background: Surface-enhanced laser desorption and ionization time-of-flight mass spectrometry (SELDI-TOF/MS), a laboratory-friendly technique, is used to identify biomarkers for cancer. The aim of the present study was to explore the application of SELDI proteomic patterns in serum for distinguishing between cases of pancreatic cancer, chronic pancreatitis, type 2 diabetes mellitus and healthy controls. Methods: Sera from 12 healthy controls, 24 patients with type 2 diabetes mellitus, 126 with pancreatic cancer, including 84 with diabetes, and...
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