Does progesterone inhibit bacteria-stimulated interleukin-8 production by lower genital tract epithelial cells?

Morgan R. Peltier, Yana Berlin, Siew C. Tee & John C. Smulian
Objective: Progesterone (P4) has been clinically shown to prevent the recurrence of preterm birth. The mechanism(s) of action is unclear, but may involve modulation of the immunologic inflammatory response of the lower genital tract. We evaluated the effects of P4 on interleukin-8 (IL-8) production by vaginal and cervical epithelial cells stimulated with bacterial species that are commonly associated with preterm birth. Methods: Vaginal and endocervical epithelial cells were incubated with up to 10,000 ng/mL P4...
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