Nichtinvasive Messung von regionalen cerebralen Oxygenerierungsänderungen während Leao´s ´corticale depression und spontaner Depolarisation bei fokaler verebraler Ischämie mit der Nah-Infrarot-Spektroskopoie

Tilo Wolf
In this thesis the optical method of Near-Infrared-Spectroscopy (NIRS) is evaluated with regards to its capability of non-invasive detection of Leão´s cortical spreading depression (CSD) and spontaneous peri-infarct-depolarizations (PID). With the NIR-spectrometer NIRO 500 (Hamamatsu, Japan) regional cerebral oxy-genation (rCBO) changes were measured during CSD in 9, and during PID in 10 barbiturate anesthatized rats. The method if NIRS that relies on oxygen-dependent absorption changes of hemo-globin and cytochrome oxydase as well as the high...
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