Photodynamic Opening of the Blood−Brain Barrier Using Different Photosensitizers in Mice

Oxana Semyachkina-Glushkovskaya, Ekaterina Borisova, Vanya Mantareva, Ivan Angelov, Ivelina Eneva, Andrey Terskov, Aysel Mamedova, Alexander Shirokov, Alexander Khorovodov, Maria Klimova, Ilana Agranovich, Inna Blokhina, Nikita Lezhnev & Jurgen Kurths
In a series of previous studies, we demonstrated that the photodynamic therapy (PDT), as a widely used tool for treatment of glioblastoma multiforme (GBM), also site-specifically opens the blood–brain barrier (BBB) in PDT-dose and age-related manner via reversible disorganization of the tight junction machinery. To develop the effective protocol of PDT-opening of the BBB, here we answer the question of what kind of photosensitizer (PS) is the most effective for the BBB opening. We studied...
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