Detection of Meningeosis neoplastica by real-time quantitation of telomerase activity

Gunter Assmann, Christian Werner, Markus Herrmann, Dunja Momber, Thomas Krenn, Daniela Lothschütz, Lars Fischer, Sandra Hess, Ralf Ketter, Wolfgang Feiden, Stefan Jung, Wolfgang Herrmann, Jörg Schubert, Michael Pfreundschuh & Thomas Widmann
Background: Analysis of cerebrospinal fluid (CSF) to discriminate between benign and malignant conditions is of fundamental importance for the physician and the patient because of the differential therapeutic options and resulting morbidity and mortality. Most human tumours demonstrate increased telomerase activity (TA). Recent technical advances in the detection of TA allow for sensitive and specific detection within 4 h. Thus, the detection of TA is suitable for routine clinical testing. Methods: This study examines TA...
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