Impact of calibration fitting models on the clinical value of chromogranin A

Simona Ferraro, Giuseppe Marano, Laura Ciardi, Chiara Vendramin, Angelo S. Bongo, Giorgio Bellomo, Patrizia Boracchi & Elia M. Biganzoli
Background: The clinical relevance of chromogranin A (CgA) concentrations depends on the analytical performance of the assay. The goal of the present study was to define the clinical involvements in CgA calibration models by evaluating the confidence intervals (CIs) for values from patients who were undergoing monitoring for disease. Methods: Thirty calibration curves for the CgA assay [immunoradiometric assay (IRMA), (CIS-BIO)] were built using linear regression (LR), and four-parameter logistic models were used to estimate...
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