flexiMAP: A regression-based method for discovering differential alternative polyadenylation events in standard RNA-seq data

Krzysztof J. Szkop, David S. Moss & Irene Nobeli
An “idealized” dataset of RNA-seq reads was created using the polyester R package (Frazee et al., 2015). This simulated dataset is clean of technical biases and fold changes between isoforms are known, allowing testing of the sensitivity limits of the method in the absence of external factors. The simulation experiment comprises 20 samples, 10 in each of two conditions. For the "main" dataset, polyadenylation sites splitting each transcript into two isoforms (short and long) were...
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