Analysis of the Ku antigen-dependent activation of reporter genes in yeast and characterization of the nuclear import signals of Ku antigen.

Jesse. Bertinato
Ku antigen (Ku70/Ku80) is a heteromeric, DNA binding protein that has been implicated in DNA repair, V(D)J recombination, tumour suppression, growth, cell cycle control, telomere maintenance and the regulation of gene transcription. Ku is a DNA binding subunit of the DNA-dependent protein kinase and functions to recruit and stimulate the catalytic subunit at appropriate DNA target sites. I present the unexpected finding that expression of human Ku fused to an ectopic activation domain broadly activated...
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