Thrombin induces cell surface exposure of the plasminogen receptor annexin II: A novel link between coagulation and fibrinolysis.

Erica Ann. Peterson
Recent studies demonstrated a role for annexin II (A2) and its ligand p11 in fibrinolysis. Since thrombin is a potent cell modulator obligately produced at the site of clot formation, the hypothesis was addressed that thrombin regulates fibrinolysis by increasing cell surface A2 and p11. Immunofluorescence and biotinylation established that thrombin significantly increases both on human umbilical vein endothelial cell (HUVEC) and human foreskin fibroblast surfaces. Intracellular antigenic analyses revealed increased p11 but unchanged A2,...
This data repository is not currently reporting usage information. For information on how your repository can submit usage information, please see our documentation.