Mitochondrial proton leak and uncoupling protein expression in transgenic mice and human obesity.

Shadi. Monemdjou
The significance of the uncoupling protein-1 (UCP1) in brown adipose tissue (BAT) thermogenesis has been well defined. However, the absence of significant amounts of BAT in adult humans, and the desire to reveal the mechanisms modulating skeletal muscle thermogenesis, led to the search for other proteins homologous to UCP1 which could also mediate thermogenesis by uncoupling oxidative phosphorylation. This search led to the discovery of Ucp2 and Ucp3 genes, as well as Ucp4 and brain...
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