Modulation of glutamatergic synaptic transmission and plasticity by sigma receptor type 1 in the CA1 region of the hippocampus

Marie-Eve Beauchemin-Turcotte
The sigma receptor (sigmaR), once considered a subtype of opioid receptor, is now described as a distinct pharmacological entity. sigma1Rs are thought to be implicated in neuropsychiatric disorders such as schizophrenia, depression as well as in learning and memory. The modulation of N-methyl-D-aspartate receptor (NMDAR) by the sigma1R has been extensively documented; however, the mechanism through which the sigma1R modulates the NMDAR has been a mystery for almost two decades. Here, I report that sigma1R...
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