The periodontal pathogen, Porphyromonas gingivalis , and the participatory role of caspase-1 in the progression of atherosclerosis

Jessica Gage
Porphyromonas gingivalis, a key pathogen in periodontal disease, promotes atherosclerosis in apolipoprotein E null (apoe-/-) mice, a well characterized mouse model of the disease. Previous studies have provided indirect evidence that P gingivalis is capable of activating the enzyme caspase-1 in vitro, while preliminary studies conducted by our laboratory have outlined a role for caspase-1 in atherosclerosis in apoe-/- mice. The present study provides direct evidence that P gingivalis is capable of activating caspase-1, and...
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