Role of Salmonella typhimurium virulence in differentially modulating immune response and host susceptibility during pregnancy

Anindita Chattopadhyay
Pregnancy poses a high risk to many infections but it is unclear how maternal immunity is modulated by pathogen virulence. Typhoid fever and gastroenteritis caused by Salmonella enterica species are increasing globally and pregnancy poses a high risk. In 129X1Sv/J mice, Salmonella enterica serovar typhimurium (ST) infection normally leads to a systemic chronic disease. However, pregnant 129X1Sv/J mice succumb rapidly to ST infection. We aimed to decipher the host and/or pathogen-associated immune mechanisms that contribute...
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