Characterisation of a conserved motif found within the Dlx cis-regulatory element URE2 and its effect on mouse URE2-lacZ activity in transgenic mice

Monique V Lavoie
The Distal-less-like genes, commonly referred to as Dlx genes, encode homeodomain transcription factors essential for the establishment of GABAergic interneurons in the ventral forebrain as well as their migration to the cortex. The cis-regulatory element URE2 (enhancer) is located upstream of Dlx1 and is thought to regulate the transcription of Dlx1 and/or Dlx2. The objective of this study was to examine a short conserved sequence within the URE2 element, corresponding to nucleotides 699-719, and to...
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