The Role of Gas3 in Skin Tumorigenesis

Beta Yadollahi
Retinoic acid (RA) plays an integral role during embryonic development, in addition to being a potential chemotherapeutic and chemopreventative agent in various cancer models due to its growth inhibitory and pro-differentiation properties. RA signaling occurs in a ligand-dependent manner through a family of nuclear receptors consisting of the RARs and RXRs. RA elicits growth inhibitory effects in transformed wild type keratinocytes, however the target genes that mediate this outcome remain largely unidentified. In order to...
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