Brain natriuretic peptide gene expression and secretion following stimulation with pro-inflammatory cytokines and conditioned medium from allo-activated mixed lymphocyte reactions

Kenneth Ka-Yout Ma
Atrial natriuretic factor (ANF) and brain natriuretic peptide (BNP) are cardiac-derived polypeptide hormones secreted by the heart. ANF and BNP play critical roles in maintaining fluid and electrolyte balance in both health and disease. Mechanisms of increasing ANF and BNP gene expression and secretion by mechanical or by vasoactive agonists have been thoroughly examined. However, recent experiments suggest that pro-inflammatory cytokines may also be important regulators of natriuretic peptide secretion. In this study, neonatal rat...
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