Ly49 Receptors and MHC-I Interactions, and their Implications in Cancer Immunosurveillance

Megan Mai Tu
Natural killer cells are part of the innate immune response, and get their name ‘natural killer’ due to their unique ability to recognize and kill aberrant cells without prior sensitization. The Ly49 receptors on NK cells are involved in both their education process and mediating their ability to recognize aberrant cells. Virally-infected and tumor cells have been shown to exhibit decreased levels of MHC-I on their cell surface. As MHC-I is expressed on all nucleated...
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