Regulation of p53-dependent apoptosis: Implications for cell fate determination and cisplatin resistance in human ovarian cancer cells in vitro

Michael Fraser
Programmed cell death (apoptosis), is a normal physiological process which involves a distinct, well-characterized signaling cascade. However, dysregulation of the apoptotic machinery is commonly observed in many pathophysiological conditions. In particular, human cancer is commonly associated with a reduced capacity of cells to undergo apoptosis in response to cell stress, leading to an abnormal accumulation of damaged cells. Human ovarian cancer is the most lethal gynecological malignancy, a statistic that is due, in part, to...
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