Variation in the cytochrome P4501A response to dioxin-like compounds in avian species

Jessica Head
Toxicological risk assessment for dioxin-like compounds in avian wildlife is currently limited by a lack of species sensitivity data. This gap in the literature can be partially attributed to difficulties associated with performing in vivo dosing studies with wild birds. For this reason, in vitro approaches for estimating dioxin sensitivity are required. One such bioassay measures the cytochrome P4501A (CYP1A) response to 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD) as ethoxyresorufin-O-deethylase (EROD) activity in cultured embryo hepatocytes. Application of...
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