Unmasking the role of ubiquitin in mammalian systems

Jan Brun
Ubiquitination is a highly regulated post-translational modification that impinges on a variety of cellular processes. Commonly known for its role in proteolysis, recent studies emphasize the versatility of ubiquitin in non-proteolysic aspects of cell function. Some of these proteolysic-independent roles have been highlighted in recent publications as being critical mediators in stress response pathways including those of DNA repair and NF-kappaB activation. In these seemingly unrelated pathways it has been shown that a noncanonical linear...
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