Diacylglycerol kinase zeta regulates Rac1-mediated remodeling of the actin cytoskeleton

Hanan Abramovici
The lipid second messengers diacylglycerol (DAG) and phosphatidic acid (PA) regulate the activity and localization of actin reorganizing proteins that participate in cellular shape changes underlying important biological processes. DAG kinases (DGKs) phosphorylate DAG to yield PA, thereby attenuating the activity of DAG-activated proteins and stimulating proteins that respond to PA. Using cell biological and biochemical approaches, I explored the hypothesis that DGKzeta regulates actin cytoskeleton remodeling in mammalian cells by associating with and promoting...
This data repository is not currently reporting usage information. For information on how your repository can submit usage information, please see our documentation.