Inflammatory immune reactivity to cereal proteins in type 1 diabetes

David E Lefebvre
Background. Type 1 diabetes (T1D) is an autoimmune disease in which a patient's immune system destroys the insulin-secreting beta-cells in the pancreas. The origin of beta-cell-specific leukocytes and the identity of the stimulatory antigens remain unknown. Disease development in individuals with genetic risk is thought to require environmental triggers. Epidemiological data and evidence from animal models suggests that exposure to dietary wheat can enhance diabetes autoimmunity. Some evidence suggests a crucial role of the gut...
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