Understanding the role of HIF-2alpha in human cancers

Aleksandra Franovic
Cancer development is a multi-step process, driven by a series of genetic and environmental alterations, which endows cells with a set of hallmark traits required for tumorigenesis. It is broadly accepted that growth signal autonomy, the first hallmark of malignancies, can be acquired through multiple genetic mutations that activate an array of complex, cancer-specific growth circuits. The superfluous nature of these pathways is thought to limit therapeutic approaches targeting cell proliferation and so this strategy...
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