Insulin Degrading Enzyme And Its Role In Atherosclerosis

Justin W Caravaggio
The type-A scavenger receptor (SR-A) plays a major role in the uptake of modified lipoproteins leading to foam cell formation and fatty streak development in artery walls. Our lab previously showed that a peptide known as insulin degrading enzyme (IDE) is able to bind the SR-A cytoplasmic domain in vitro. The present study provides evidence that male low density lipoprotein receptor-null (LDLr-/-) mice on a high fat diet, generate significantly more atherosclerotic lesion in aortic...
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