Vascular progenitor cell and extracellular matrix protein interactions in cancer

Laura E Labonte
Vascular progenitor cells (VPCs) facilitate angiogenesis and vascular repair in damaged tissues where inflammatory cytokines coordinate healing through VPC mobilization. VPCs also facilitate tumor angiogenesis and induce angiogenic switching in metastatic sites. VPC binding to extracellular matrix proteins enriched in injured healing tissues and metastatic sites and the participation of integrins in this binding was investigated. VPC binding profiles on fibronectin and laminin of "healthy" controls was different from those of "cancer" patients and patients...
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