The Functional Characterization of Wdr68 Regulation of Pax7 Activity in Myogenesis

Anna Francina Jackson
In response to tissue trauma, quiescent satellite cells in adult skeletal muscle undergo proliferative activation and migrate to the site of injury where they differentiate and fuse to mend and replace damaged myofibers. The tightly synchronized expression of myogenic regulatory factors plays a critical role in orchestrating the regenerative process. In recent studies, we identified the transcription factor Pax7 as able to recruit the Wdr5-Ash2L-MLL2 histone methyltransferase complex to the -57.5kb Myf5 enhancer and to...
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