Effect of ischemia/reperfusion on the rat intrarenal renin-angiotensin system.

Jimmy. Kontogiannis
Proliferation and differentiation of tubular cells occur after renal ischemia/reperfusion. Angiotensin II has multiple growth effects on different renal cell types, and also regulates renal blood flow In particular, proximal tubular cells locally synthesize angiotensin II, which can bind to AT$\sb1$ receptors in an autocrine/paracrine fashion. The function of the AT$\sb2$ receptor is unknown, but is linked to apoptosis in other tissues. In the current study, gene expression for intrarenal angiotensinogen, cortical AT$\sb1$ receptor and...
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