Structural studies of anti-tumour antibody R24.

Marcin Jerzy. Kaminski
The murine monoclonal antibody R24 and mouse-human Fv-IgG1($\kappa)$ chimeric monoclonal antibody chR24 are specific for the cell surface tumour antigen disialoganglioside GD3. X-ray diffraction and surface plasmon resonance experiments have been employed to study the mechanism of "homophilic binding" in which molecules of R24 recognize and bind to other molecules of R24 through the heavy chain variable domains. The relationship between GD3-binding and the homophilic-binding domain, and the mechanism of the behaviour of chR24 mutants...
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