Effect of GM-CSF on RNA and protein in human peripheral blood granulocytes.

Randy T. Cowling
Human granulocytes are the most abundant circulating leukocyte, and are critical in protection against microbial infection. These cells are terminally differentiated and highly specialized, possessing very little RNA and protein synthesis. It was believed that transcription and translation were unnecessary for granulocyte functioning, but it is now understood that these processes play a role in some responses. The cytokine GM-CSF, which can be released at inflammatory sites, is an important granulocyte effector. At least one...
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