Evidence for the presence of large-scale deletion mutations in a murine tumour model.

Sherry Anne. Weppler
In order to study mutagenicity occurring within a tumour environment, our lab has developed the Mutated murine tumour model, which is able to sensitively detect mutations at a genetically manipulated hprt locus. Prior to my work, the X-linked hprt gene in the Mutated cell lines was thought to be heterozygous based on high sensitivity to induction of mutations by ionizing radiation and the identification of 3 X-chromosomes by fluorescent in situ hybridization. In order to...
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