Molecular basis of the nephrotoxicity of aminoglycoside antibiotics: A Fourier transform infrared spectroscopic investigation.

Komal. Gurnani
The interaction of gentamicin with daptomycin and PI dispersions was investigated by FTIR spectroscopy. We found no evidence of a direct interaction involving the neutralization of the aspartate residues of daptomycin by gentamicin and the amide I band of daptomycin did not reveal significant conformational changes of its peptidic moiety. On the other hand, daptomycin readily inserts within bilayers of PI, dimyristoylphosphatidylglycerol or dipalmitoylphosphatidylcholine, as judged from its influence on the fluidity of these bilayers....
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