Studies of blood monocytes from patients infected with the human immunodeficiency virus-1 (HIV-1).

Yuenan. Shen
To determine if blood monocytes from HIV-1 seropositive patients contain HIV-1 antigen and genome, we separated monocytes and T cell subsets using monoclonal antibodies (mAbs) conjugated to magnetic beads and by monocyte adherence to glass. We found: (1) Monocytes cultured without depletion of CD4$\sp+$ T cells (11 of 11 patients) were HIV-1 antigen positive and showed dramatically increased spontaneous formation of MGCs. (2) Monocytes cultured after depletion of CD4$\sp+$ T cells (3 experiments) were HIV-1...
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