The role of Xist and CHD-1 in gene silencing.

Helen H. Tai
Gene silencing is a stable and heritable form of repression of gene expression that is thought to be mediated by higher order chromatin structures. This thesis consists of two separate studies on gene silencing. The first chapter deals with X chromosome inactivation which is a particular case of gene silencing where almost all the genes one X chromosome are inactivated early in the development of female mammals. The Xist gene is a candidate gene for...
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